Long-term Study Finds Midlife Chronic Conditions Increase Cancer Risk and Mortality
Recent research from Memorial Sloan Kettering Cancer Center and the University of California, Los Angeles, highlights the significant impact of chronic health conditions during midlife on future cancer risk and mortality. The study, titled "Comorbidity in Midlife and Cancer Outcomes," analyzed data from a large cohort of nearly 129,000 adults aged 55 to 74, enrolled between 1993 and 2001 across the United States. Participants reported histories of 12 different comorbidities, categorized into cardiovascular, respiratory, gastrointestinal, liver-related, and metabolic conditions.
Over a median follow-up period of 20 years, findings showed that a history of respiratory and cardiovascular diseases was associated with a modest but significant increase in overall cancer risk. Specifically, respiratory conditions increased the hazard ratio (HR) for cancer by 1.07, and cardiovascular conditions by 1.02. Liver conditions showed the strongest link, particularly with liver cancer, where the risk was over five times higher (HR 5.57). Meanwhile, metabolic conditions were associated with higher risks for nine specific cancers, including increases in both lung and prostate cancers, as well as a decreased risk for four other types.
In addition to incidence, comorbidities also influenced cancer-related mortality. Respiratory, cardiovascular, and metabolic illnesses were linked to higher odds of cancer-specific death, emphasizing the importance of managing chronic diseases to improve long-term outcomes. The study underscores the potential benefits of integrating comprehensive chronic disease screening and management into routine healthcare, which could help in early detection and prevention of cancer.
This research adds to the growing body of evidence that health in midlife significantly influences future disease trajectories, including cancer. Public health strategies that focus on early diagnosis and management of chronic conditions may reduce cancer incidence and mortality, ultimately fostering better health in later years.
Source: https://medicalxpress.com/news/2025-04-term-links-chronic-conditions-midlife.html
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
Breakthrough Compound Shows Potential in Preventing Premature Births in Mice
Researchers at the University of Montreal have developed a novel peptide, HSJ633, showing promising potential to prevent premature labor in mice, potentially transforming neonatal health care worldwide.
New COVID Variant NB.1.8.1 Escalates Infections: What You Need to Know
A new COVID-19 variant, NB.1.8.1, is spreading globally and may affect infection rates. Learn about its origins, characteristics, symptoms, and what you can do to stay protected.
Early Childhood Exposure to Endocrine Disruptors May Influence Food Preferences
Early exposure to endocrine-disrupting chemicals during childhood can alter brain pathways, increasing the likelihood of developing unhealthy food preferences and obesity. Learn about the recent animal study revealing these impacts and the importance of reducing chemical exposure during early life.
The Impact of Childhood Maltreatment on Biological Aging and Social Development
Recent research reveals how childhood maltreatment accelerates biological aging and hampers social development, highlighting the importance of early detection and intervention for vulnerable children.