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Limitations of Current Biomarkers in Assessing Post-Pregnancy Heart Failure Risk

Limitations of Current Biomarkers in Assessing Post-Pregnancy Heart Failure Risk

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New research questions the effectiveness of traditional biomarkers like NT-proBNP for predicting heart failure in women after complicated pregnancies, emphasizing the need for new screening methods.

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Recent research indicates that the biomarkers traditionally used to predict heart failure risk may not be effective for women following complicated pregnancies, such as those affected by hypertension or diabetes. A study published in JAMA Cardiology analyzed over 4,000 pregnancies across various medical centers, focusing on NT-proBNP, a common biomarker for heart failure. While approximately 1 in 17 women exhibited elevated levels of NT-proBNP years after childbirth — suggesting cardiac stress — pregnancies with conditions like preeclampsia, hypertension, or gestational diabetes did not show a corresponding increase in this biomarker. Contrary to expectations, women with these pregnancy complications tended to have lower levels of NT-proBNP, which challenges its reliability in postpartum cardiovascular screening.

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