Mia's Feed
Medical News & Research

Innovative Blood Test Enables Early Detection of Multiple Cancers via Cell-Free DNA

Innovative Blood Test Enables Early Detection of Multiple Cancers via Cell-Free DNA

Share this article

A novel blood test utilizing cell-free DNA analysis offers high accuracy in detecting multiple cancer types early, promising to improve diagnosis and treatment outcomes.

2 min read

A groundbreaking blood test developed by researchers from Geneseeq and Chinese medical institutions offers a promising noninvasive method for detecting various cancers at early stages. Utilizing advanced whole-genome sequencing and machine learning, this multi-cancer early detection (MCED) test analyzes cell-free DNA (cfDNA) fragments circulating in the bloodstream, which tumors shed into the blood.

In validation studies, the test demonstrated high accuracy, with an 87.4% sensitivity and 97.8% specificity in identifying cancer among a diverse cohort. It successfully predicted the tissue of origin in approximately 83% of cases, supporting its potential utility in guiding clinical decisions.

The study, published in Nature Medicine, involved a retrospective training phase with thousands of cancer patients and controls, followed by validation using independent cohorts. Ultimately, a prospective analysis enrolled nearly 3,700 asymptomatic individuals in China, where 43 cancer cases were identified within a year.

The test performed particularly well for cancers often diagnosed late, such as liver, ovarian, pancreatic, and lung cancers, with sensitivities ranging from 76.9% to 100%. Its ability to detect cancers early and accurately determine their origin could significantly improve early intervention and treatment outcomes.

By leveraging features like cfDNA fragment size, methylation patterns, copy number variations, and nucleosome positioning, the machine learning models achieved robust performance, even for early-stage tumors. The researchers suggest that this MCED test has the potential to transform cancer detection, enabling timely diagnosis and personalized treatment strategies.

This innovative approach represents a significant advancement in cancer screening, especially for cancers lacking effective routine screening methods. Further clinical trials and regulatory evaluations are underway to facilitate its integration into routine healthcare.

Source: https://medicalxpress.com/news/2025-06-blood-multiple-cancer-cell-free.html

Stay Updated with Mia's Feed

Get the latest health & wellness insights delivered straight to your inbox.

How often would you like updates?

We respect your privacy. Unsubscribe at any time.

Related Articles

Challenges in Monitoring Measles Spread in Florida Due to Lack of Public Data

Florida's removal of public disease-tracking data has created gaps in monitoring measles and other infectious diseases, raising concerns about outbreak detection and public health safety.

Enhanced Infectious Disease Testing in Migrants Reduces Transmission, Study Finds

A groundbreaking study demonstrates that routine, comprehensive infectious disease testing among migrants in primary care settings significantly improves early detection and reduces community transmission, enhancing public health outcomes.

How Brain Stimulation Can Reduce Symptoms of Parkinson's Disease

New research explores how targeted brain stimulation, including optogenetics, can activate motor pathways outside traditional regions to alleviate symptoms of Parkinson's disease and improve mobility.

Novel Molecule Demonstrates Potential to Reverse Age-Related Cognitive Decline in Animal Studies

A new study highlights the potential of the molecule Hevin to reverse cognitive impairments related to aging and dementia in animal models, focusing on enhancing neural connections independently of amyloid plaques.