MedDiet Significantly Reduces Psoriasis Symptoms in Clinical Trial Participants

A recent clinical trial has demonstrated that following a Mediterranean diet can lead to a substantial improvement in psoriasis symptoms. Psoriasis is a chronic inflammatory skin condition affecting over 60 million people worldwide, characterized by red, scaly patches and persistent itchiness. In this study, researchers explored the impact of diet on psoriasis severity, focusing on a diet rich in plant-based foods, extra-virgin olive oil, moderate fish, and poultry intake.

The trial, conducted at a dermatology clinic in Madrid, involved 38 adults with mild to moderate psoriasis, assessed using the Psoriasis Area and Severity Index (PASI). Participants were randomly divided into two groups: one followed a guided 16-week Mediterranean diet, while the control group received standard low-fat diet advice without specific guidance. Results showed that nearly half (47%) of those on the Mediterranean diet experienced at least a 75% reduction in skin symptoms, known as PASI 75, compared to none in the control group. Remarkably, these improvements occurred independently of significant weight loss.

The study highlights that the benefits of the Mediterranean diet may stem from its anti-inflammatory and cardiometabolic properties, which might directly influence the biological pathways involved in psoriasis. This diet provides an abundance of antioxidants, such as vitamins C, E, and β-carotene, and plant compounds like polyphenols found in fruits, vegetables, nuts, whole grains, olive oil, and fish. These components help reduce oxidative stress and inflammation, potentially calming the immune system overactivity characteristic of psoriasis.

Psoriasis is driven by immune system dysfunction, where overactive T-cells mistakenly attack the body's skin cells, leading to rapid cell production and inflammation. By supporting immune regulation and reducing inflammation, the Mediterranean diet offers a promising complementary approach alongside conventional therapies.

The trial's findings, published in JAMA Dermatology, suggest that dietary interventions can be an effective part of holistic psoriasis management. Incorporating healthy eating patterns like the Mediterranean diet may improve not only skin health but also overall well-being by enhancing sleep quality and reducing anxiety.

This study marks a significant step forward in understanding how lifestyle factors influence autoimmune skin conditions and encourages further research into diet-based therapies for psoriasis.