Women with Cirrhosis and Ascites Experience Poorer Emotional Quality of Life

Recent research published in the August issue of the American Journal of Gastroenterology highlights significant gender differences in the health-related quality of life (HRQoL) among patients with cirrhosis and ascites. The study found that women suffering from these conditions report worse emotional well-being compared to men, although their daily functioning remains comparable.

The study involved 576 outpatients, including 392 men and 184 women, all with recurrent or refractory ascites requiring repeated large-volume paracenteses. Despite similar severity of liver disease, complications, and frailty scores, women experienced a higher burden of symptoms related to ascites, as indicated by the Ascites Questionnaire, with scores averaging 66 ± 21 compared to 60 ± 21 in men. Additionally, depression was notably more prevalent among women, with 35% reporting feelings of depression versus 22% of men. Interestingly, while their mental health was more affected, women maintained their daily activity levels just as effectively as men, as shown by assessments like the Duke Status Activity Index and the Godin Leisure Activity Index.

This research underscores the importance of considering gender-specific experiences when managing cirrhosis and ascites. It suggests that tailored patient-centered approaches are necessary to address the emotional health needs of women with this condition. The authors emphasize that further investigation is needed to determine whether these reduced HRQoL measures are associated with increased mortality risk.

Overall, the findings advocate for comprehensive care that includes psychological support, especially for female patients suffering from cirrhotic ascites, to improve their emotional well-being and overall quality of life.

Source: https://medicalxpress.com/news/2025-08-worse-emotional-health-quality-life.html