New Program Supports Women with Obesity Planning Pregnancy

Northwestern Medicine has introduced a dedicated initiative aimed at supporting women with obesity who are considering pregnancy. This program, known as PEARL (Preconception and Early Assessment Care Rooted in Lifestyle Management), is designed to address weight-related concerns and improve health outcomes for mothers and their babies.

Women facing higher levels of body fat often encounter challenges with conception and are at increased risk for complications during pregnancy. The PEARL program seeks to provide personalized care by focusing on lifestyle modifications, weight management, and metabolic health optimization. According to Dr. Christina Boots, a reproductive endocrinology specialist involved in the program, about one-third of her infertility patients struggle with obesity. However, many women also experience issues like insulin resistance and prediabetes even if they do not meet the formal criteria for obesity.

The program is available to patients with a body mass index (BMI) above 27, which considers factors like height and weight to estimate body fat. For example, at an average height of 5 feet 3.5 inches, a woman would qualify if she weighs 157 pounds or more.

Addressing the stigma around weight, Dr. Boots emphasizes that health is achievable at every size. The goal is not solely weight loss but improving overall health to facilitate safe pregnancies. The program involves a team of clinicians including obesity medicine specialists and maternal-fetal medicine experts, who work together to support women whether they aim to lower their BMI to increase fertility or manage health conditions like blood pressure and cholesterol.

Many women have already benefited from the program. One patient, initially with a BMI of 58, managed to reduce her BMI to 48 within a year and is now preparing for IVF. The program also considers the safety implications of higher BMIs during procedures like egg retrieval, where anesthesia risks are higher. Sometimes, using weight-loss medications can help, though their safety during pregnancy remains under investigation; women are advised to stop such medications at least two months before conception.

Overall, PEARL promotes an inclusive, supportive approach that respects women’s health choices without stigmatization. It aims to enhance preconception health, reduce pregnancy risks, and support women through their reproductive journey with personalized, compassionate care.

Source: https://medicalxpress.com/news/2025-07-patients-obesity-pregnancy.html