Innovative Pen-Like Device for Rapid Detection of Opioids via Skin Analysis

A groundbreaking technological advancement presented in boratory Analytical Chemistryids in the fight against opioid overdose crises. Researchers have developed a portable, pen-shaped device capable of quickly and non-invasively extracting and analyzing molecules from the skin's surface to detect opioid substances, such as fentanyl, morphine, and oxycodone.

Opioids are the primary drugs associated with overdose fatalities in the United States, often detected through blood, saliva, or urine tests, which can be time-consuming and require laboratory processing. This new tool, inspired by the clinical MasSpec Pen technology used in cancer tissue analysis, offers a rapid alternative by directly sampling the skin.

The modified MasSpec Pen works by depositing a tiny droplet of water and ethanol onto the skin, which then collects molecules indicative of opioid use over a span of just three seconds. The collected sample is immediately aspirated into a collection vial and can be analyzed on-site using mass spectrometry highly sensitive method for molecular detection. If needed, samples can also be stored for later examination.

Initial testing demonstrated promising results. When applied to volunteers with known opioid exposure, the device detected fentanyl in seven out of eight skin samples, compared to its presence in all urine samples and in some saliva samples. Although the detection levels from skin samples were lower than traditional biological fluids, the device's ease of use and portability highlight its potential for field or clinical applications.

The researchers acknowledge factors such as skin type, cleanliness, and timing of drug intake may influence results and plan further studies to optimize detection limits and expand understanding. Some of the team members hold patents related to the MasSpec Pen and are involved in commercializing this technology.

This development could enable earlier interventions for individuals at risk of overdose or requiring substance use treatment, providing a quick, non-invasive, and accessible screening method outside traditional laboratory settings.

Source: https://medicalxpress.com/news/2025-06-handy-pen-tool-opioids-skin.html