Novel Proteomic Insights into Post-Traumatic Stress Disorder via Multi-Omic Analysis
Recent research employing a comprehensive multi-omic approach has shed light on the molecular underpinnings of post-traumatic stress disorder (PTSD). Conducted by scientists at Yale School of Medicine, the study analyzed brain tissue from individuals diagnosed with PTSD, major depression (MDD), and neurotypical controls across multiple regions, including the dorsolateral prefrontal cortex and subgenual anterior cingulate cortex. Their analysis integrated genetic, transcriptional, post-transcriptional, and proteomic data to identify differential expression patterns.
The findings revealed specific proteins and co-expression networks disrupted in PTSD, with integrative analysis highlighting the role of microRNA hsa-mir-589 as an upstream regulator affecting neuronal protein networks, including the GABA transporter SLC32A1. Moreover, the study identified an enrichment of risk genes associated with other psychiatric conditions, such as depression, autism, and bipolar disorder, within PTSD-related protein networks, suggesting shared molecular pathways.
This systems biology approach is pioneering in PTSD research, providing detailed insights into the disease's molecular landscape. The research underscores the significance of immune and neuronal signaling pathways and suggests new avenues for biomarker development and targeted therapies. According to senior author Dr. Matthew Girgenti, these discoveries advance our understanding of brain-specific molecular dysregulation in PTSD and related disorders, paving the way for future therapeutic strategies.
The study’s implications extend beyond PTSD, highlighting common molecular mechanisms across psychiatric illnesses, which could influence future research and treatment approaches. The work was published in Genome Medicine and represents a significant step forward in psychiatric genomics and proteomics, emphasizing the importance of multi-omics in unraveling complex brain disorders.
Source: https://medicalxpress.com/news/2025-05-multi-omic-approach-implicates-protein.html
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
Japan's Oldest Person at 114: Retired Doctor and Olympic Torchbearer
Meet Japan's oldest living person, 114-year-old retired doctor and former Olympic torchbearer Shigeko Kagawa, whose life exemplifies Japan’s remarkable longevity and active aging.
Innovative Use of Nine Molecular Techniques Enables Rapid, Personalized Cancer Treatment
A groundbreaking study utilizing nine molecular techniques within four weeks enables highly personalized treatment strategies for complex cancers, marking a major advancement in precision oncology.
Revolutionary Brain-to-Computer 'Electroceuticals' Show Promise in Restoring Cognitive Functions
Emerging research demonstrates how brain-to-computer electroceuticals can improve learning and cognitive flexibility, paving the way for novel therapies for cognitive disorders.
Innovative Method Fast-Tracks Measurement of Cell Density to Assess Health and Developmental States
MIT researchers have developed a fast, large-scale method to measure cell density, revealing important insights into cell health, immune activation, and drug responses. This breakthrough enhances our understanding of cellular states and could revolutionize biomedical research.