Novel Proteomic Insights into Post-Traumatic Stress Disorder via Multi-Omic Analysis
Recent research employing a comprehensive multi-omic approach has shed light on the molecular underpinnings of post-traumatic stress disorder (PTSD). Conducted by scientists at Yale School of Medicine, the study analyzed brain tissue from individuals diagnosed with PTSD, major depression (MDD), and neurotypical controls across multiple regions, including the dorsolateral prefrontal cortex and subgenual anterior cingulate cortex. Their analysis integrated genetic, transcriptional, post-transcriptional, and proteomic data to identify differential expression patterns.
The findings revealed specific proteins and co-expression networks disrupted in PTSD, with integrative analysis highlighting the role of microRNA hsa-mir-589 as an upstream regulator affecting neuronal protein networks, including the GABA transporter SLC32A1. Moreover, the study identified an enrichment of risk genes associated with other psychiatric conditions, such as depression, autism, and bipolar disorder, within PTSD-related protein networks, suggesting shared molecular pathways.
This systems biology approach is pioneering in PTSD research, providing detailed insights into the disease's molecular landscape. The research underscores the significance of immune and neuronal signaling pathways and suggests new avenues for biomarker development and targeted therapies. According to senior author Dr. Matthew Girgenti, these discoveries advance our understanding of brain-specific molecular dysregulation in PTSD and related disorders, paving the way for future therapeutic strategies.
The study’s implications extend beyond PTSD, highlighting common molecular mechanisms across psychiatric illnesses, which could influence future research and treatment approaches. The work was published in Genome Medicine and represents a significant step forward in psychiatric genomics and proteomics, emphasizing the importance of multi-omics in unraveling complex brain disorders.
Source: https://medicalxpress.com/news/2025-05-multi-omic-approach-implicates-protein.html
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
Study Finds Spironolactone Does Not Lower Cardiovascular Risk in Dialysis Patients
A large international trial shows that spironolactone does not significantly reduce cardiovascular events in patients on dialysis, informing future treatment approaches.
Recall Issued for Goodles Mac & Cheese Due to Hidden Allergen Risks
Goodler Foods has recalled multiple lots of its mac and cheese products due to undeclared milk and cashew allergens, posing health risks for sensitive individuals. Consumers should check product labels and avoid eating affected items.
Innovative Study Demonstrates Creation of Functional Eggs from Human Skin Cells to Address Infertility
A pioneering study from Oregon Health & Science University has successfully created functional human eggs from skin cells, opening new possibilities for infertility treatments and reproductive options.
Analysis Reveals Lack of Transparency and Penalties for Serious Errors in Rehab Hospitals
A recent analysis uncovers serious safety issues in rehab hospitals, including patient deaths and medication errors, with limited penalties and transparency from federal agencies. Learn about the risks and oversight gaps in this profitable industry.