Metformin's Potential to Enhance Strength and Mobility in Aging Men with Disabilities

Metformin, a widely used medication for managing type 2 diabetes, is showing promising potential beyond blood sugar regulation. Recent research conducted by the University of Sharjah suggests that metformin may significantly improve muscle strength and mobility in older men with functional disabilities. The study found that metformin enhances handgrip strength and overall physical performance, partly by supporting the health of neuromuscular junctions (NMJs)—the critical interface where nerves communicate with muscles.

The researchers highlight that these effects are particularly relevant for geriatric men, as NMJ deterioration is a common feature of aging that contributes to muscle weakness and reduced mobility. The study demonstrated that metformin helps in stabilizing and restoring NMJs, which leads to better muscle function.

In the clinical trial, 220 non-diabetic men were initially considered, with 148 participating after exclusions. Participants in the metformin group received 1700 mg daily for 16 weeks, and their progress was compared with a placebo group. The findings revealed notable improvements in handgrip strength, walking speed, and overall physical capacity among those taking metformin. Moreover, biomarkers indicative of NMJ degradation decreased, suggesting enhanced nerve-muscle communication.

Lead researcher Rizwan Qaisar explained that metformin might be supporting movement machinery in older adults, offering a new perspective on its benefits. Another co-author, Firdos Ahmad, compared NMJs to the foundation of a building, emphasizing that strengthening this foundation could help maintain muscle health in aging populations.

While the study provides encouraging evidence, the researchers acknowledge its limitations, notably the exclusive focus on men, which restricts generalization to women. Further research is needed to determine if these benefits extend across genders.

Overall, this study opens new avenues for using metformin as a tool to combat age-related muscle decline, potentially improving quality of life for seniors by enhancing strength and mobility. The findings add to the growing understanding of the drug's protective effects on skeletal muscle and suggest a novel role in supporting physical capacity in the elderly.

Source: https://medicalxpress.com/news/2025-05-metformin-strength-mobility-geriatric-men.html