Achieving Low Disease Activity in Lupus Nephritis: A Step Forward in Management
Achieving a low disease activity state in lupus nephritis significantly reduces relapse risk and helps preserve kidney function, offering hope for better long-term management of the condition.
Recent research highlights that achieving a low disease activity state (LLDAS) in patients with lupus nephritis is possible and is associated with improved outcomes. A study published online in Arthritis Care & Research on July 20, 2025, demonstrates that both complete renal response (CRR)/partial renal response (PRR) and LLDAS are linked to higher relapse-free survival rates. The study involved 245 adult lupus nephritis patients, with findings revealing that 40% achieved CRR, 10% achieved PRR, and 49% attained LLDAS after 12 months.
The research, led by Chak Kwan Cheung from The University of Hong Kong, shows that attaining these treatment targets independently reduces the risk of disease relapse and helps preserve kidney function long-term. Specifically, achieving CRR/PRR and LLDAS was associated with hazard ratios of 0.31 and 0.38, respectively, indicating a significant decrease in relapse risk.
Importantly, the study emphasizes that LLDAS can be an attainable and effective treatment goal in lupus nephritis management. The authors suggest that aiming for LLDAS, either alone or alongside CRR/PRR, leads to better patient outcomes, including a lower chance of disease relapse and better renal function preservation.
This evidence encourages clinicians to incorporate LLDAS into treatment protocols, helping improve long-term quality of life for patients with lupus nephritis. For further details, see the full study in Arthritis Care & Research (DOI: 10.1002/acr.25611).
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
Resource-Scarce Neighborhoods and Increased Risk of Gestational Diabetes
Research shows that residents of resource-deprived neighborhoods are at higher risk of developing gestational diabetes during pregnancy, highlighting the impact of social determinants on maternal health.
Davos Alzheimer's Collaborative Unveils Five-Year Strategy to Boost Brain Health in Africa and Globally
Davos Alzheimer's Collaborative has launched a five-year plan to enhance brain health globally, focusing on early detection, prevention, and system transformation, with a special emphasis on Africa’s development.
Innovative CAR-T Cell Therapy Shows Promise for Autoimmune Hemophilia Treatment
A groundbreaking case at Hannover Medical School demonstrates the successful use of CAR-T cell therapy to treat acquired hemophilia A, offering new hope for autoimmune blood disorders resistant to conventional treatments.
Research Highlights Risks of Vitamin B12 Deficiency During Pregnancy
New research from Nottingham Trent University reveals that vitamin B12 deficiency during pregnancy may increase risks for metabolic disorders, emphasizing the importance of balanced nutrition.