Achieving Low Disease Activity in Lupus Nephritis: A Step Forward in Management

Recent research highlights that achieving a low disease activity state (LLDAS) in patients with lupus nephritis is possible and is associated with improved outcomes. A study published online in Arthritis Care & Research on July 20, 2025, demonstrates that both complete renal response (CRR)/partial renal response (PRR) and LLDAS are linked to higher relapse-free survival rates. The study involved 245 adult lupus nephritis patients, with findings revealing that 40% achieved CRR, 10% achieved PRR, and 49% attained LLDAS after 12 months.

The research, led by Chak Kwan Cheung from The University of Hong Kong, shows that attaining these treatment targets independently reduces the risk of disease relapse and helps preserve kidney function long-term. Specifically, achieving CRR/PRR and LLDAS was associated with hazard ratios of 0.31 and 0.38, respectively, indicating a significant decrease in relapse risk.

Importantly, the study emphasizes that LLDAS can be an attainable and effective treatment goal in lupus nephritis management. The authors suggest that aiming for LLDAS, either alone or alongside CRR/PRR, leads to better patient outcomes, including a lower chance of disease relapse and better renal function preservation.

This evidence encourages clinicians to incorporate LLDAS into treatment protocols, helping improve long-term quality of life for patients with lupus nephritis. For further details, see the full study in Arthritis Care & Research (DOI: 10.1002/acr.25611).