Long-Term Cardiac Microvascular Changes in Severe COVID-19 Survivors

Recent research from Karolinska Institutet highlights persistent cardiac complications in patients who endured severe COVID-19. The study examined approximately 40 individuals from a post-COVID outpatient clinic using advanced cardiac imaging techniques. Findings revealed reduced blood flow through the heart muscle and impaired pumping function compared to matched controls, suggesting the presence of small vessel disease long after initial infection.

Particularly, patients exhibited signs of microvascular dysfunction, which may contribute to ongoing symptoms like fatigue and exercise intolerance. Midventricular perfusion maps demonstrated globally diminished perfusion under stress conditions, indicating widespread microvascular impairment.

The research emphasizes the importance of understanding the underlying mechanisms of enduring COVID-19 symptoms. As Associate Professor Jannike Nickander explains, small vessel disease could be a key factor and a potential target for therapeutic intervention. Her team is now investigating the molecular pathways involved and exploring the interactions between cardiac and pulmonary pressures in these patients.

This study highlights the need for ongoing monitoring and research into cardiovascular health in COVID-19 survivors, aiming to improve treatment strategies and patient outcomes.

Source: https://medicalxpress.com/news/2025-06-small-vessel-disease-term-severe.html