Simple Supplement May Protect Against Muscle Loss During Weight-Loss Medication

A recent study from the University of Alberta suggests that incorporating a ketone supplement could significantly reduce muscle loss associated with the use of weight-loss drugs like semaglutide, commonly found in medications such as Ozempic, Wegovy, and Rybelsus. These drugs are effective at promoting fat loss but often lead to unintended reduction in skeletal muscle mass and even affect heart muscle, raising concerns about long-term health impacts.

In the study, researchers observed that while weight loss from these medications predominantly involves fat reduction, a notable decline in muscle mass—up to 40% of total weight loss—also occurs. More alarmingly, the heart muscle was found to shrink as well, which could have adverse effects, especially for individuals with pre-existing heart conditions.

To address this issue, scientists explored the role of ketones, natural energy sources produced by the liver during fasting or low-carb diets. Ketones are vital in preserving skeletal muscle mass, and their supplementation was tested using a ketone ester, which the body converts into ketones.

In experiments with obese mice, combined treatment with semaglutide and a ketone ester demonstrated remarkable results. The animals experienced less muscle and cardiac mass loss compared to those receiving semaglutide alone. Although the overall weight loss was slightly lower, the key improvement was the preservation of muscle tissue, suggesting that ketone supplementation could make weight-loss drugs safer.

The underlying mechanism involves mitochondria—the cells' energy factories. Semaglutide appears to impair mitochondrial function, leading to muscle breakdown for energy. Ketones help maintain mitochondrial health, thus protecting muscles from wasting. This breakthrough points towards a promising strategy to enhance the safety profile of popular weight-loss medications, which have become widely used globally.

This innovative approach highlights the potential of ketone therapy as an adjunct to existing weight-loss treatments, aiming to optimize fat loss while minimizing muscle loss. Further research is needed to explore its effectiveness and safety in humans, but the findings are a promising step toward safer obesity management.

Source: https://medicalxpress.com/news/2025-10-simple-supplement-muscle-loss-weight.html