New Insights into Treatment Resistance in ER+ Breast Cancer: The Role of the JNK Pathway
A new study uncovers how inactivation of the JNK pathway enables ER+ breast cancer cells to evade treatment, offering potential for targeted therapies and improved patient outcomes.
Researchers at the Garvan Institute of Medical Research have made a significant discovery that could influence the future of breast cancer treatment. Their study highlights how the inactivation of a critical cellular stress response, involving the JNK pathway, enables estrogen receptor-positive (ER+) breast cancer cells to evade current therapies. ER+ breast cancer, which accounts for about 70% of all breast cancer cases, often responds well to initial treatment. However, resistance to endocrine therapies frequently leads to metastatic recurrence and mortality, with over 2,000 deaths annually in Australia.
The research team conducted a comprehensive genome-wide CRISPR knockout screen to identify genes responsible for treatment resistance. They found that when key components of the JNK pathway, including the gene MAP2K7, are disabled, cancer cells continue to grow despite receiving combination treatments such as endocrine therapy and CDK4/6 inhibitors. This disruption hampers the pathway's ability to trigger cell death or growth arrest signals, allowing tumors to survive and spread.
Further analysis of tumor samples from 78 patients confirmed that low activity of the JNK pathway correlates with poorer treatment responses. These findings suggest that assessing JNK pathway activity could serve as a predictive marker for treatment efficacy, helping clinicians tailor therapies for high-risk ER+ breast cancer patients.
Interestingly, while the JNK pathway is often associated with promoting cancer in some contexts, this study reveals it can also act as a tumor suppressor in ER+ breast cancer. The loss of pathway function appears to be a key driver of treatment resistance. The team is now exploring alternative therapeutic strategies for patients with suppressed JNK activity, aiming to develop more personalized and effective interventions.
Overall, this research paves the way for improved diagnostic tools and targeted treatments, potentially reducing recurrence rates and enhancing survival outcomes for breast cancer patients. The findings were published in the Journal of Experimental & Clinical Cancer Research (source).
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
Cost Comparison: Multitarget Stool DNA Tests vs. FIT for Early Detection of Colorectal Cancer
A new study compares the costs of multitarget stool DNA tests and FIT for early detection of colorectal cancer, revealing higher expenses associated with DNA-based methods despite their increased sensitivity. The findings highlight the importance of cost-effectiveness in colorectal cancer screening strategies.
Consuming Animal Protein Post-Workout Enhances Recovery, New Study Shows
A new study highlights that consuming animal protein, such as pork, after intense training can significantly enhance recovery, reduce muscle soreness, and improve hormonal responses, compared to plant-based proteins. Fortifying plant-based meals with essential amino acids and creatine may bridge the gap for vegetarians and vegans.
Study Shows Same-Day Discharge Safe for Older Women Undergoing Breast Cancer Mastectomy
New research reveals that older women undergoing mastectomy for breast cancer can safely leave hospitals on the same day, reducing unnecessary overnight stays without increasing complications. This approach enhances recovery and hospital resource efficiency.
Remote Healthcare Accelerates Access to Essential Medications for Heart Failure Patients
A groundbreaking study shows remote digital programs can help heart failure patients access vital medications faster and more efficiently, improving outcomes without increasing hospital visits.