New Clinical Guidelines for Postmastectomy Radiation Therapy in Breast Cancer Patients
New guidelines published in 2025 outline evidence-based recommendations for postmastectomy radiation therapy in breast cancer treatment, emphasizing personalized approaches and advanced planning techniques.
Recently published in the journal Practical Radiation Oncology on September 16, 2025, a comprehensive set of clinical practice guidelines has been established for the application of postmastectomy radiation therapy (PMRT). Developed by a multidisciplinary task force led by Dr. Rachel B. Jimenez from Massachusetts General Hospital, these recommendations aim to optimize treatment strategies for breast cancer patients undergoing mastectomy.
The guidelines emphasize that PMRT is highly indicated for patients with node-positive breast cancer, and may also benefit some patients with node-negative disease following upfront mastectomy. For those with locally advanced disease or residual nodal disease after neoadjuvant systemic therapy, PMRT is recommended to reduce the risk of recurrence. Additionally, for patients with clinical tumor stages T1-3N1 or T3N0 who have negative nodes after systemic therapy, PMRT is conditionally advised.
Treatment planning advocates for the use of advanced imaging, specifically computed tomography-based volumetric planning with three-dimensional conformal radiotherapy. When goal achievement is not possible with 3D conformal RT, intensity-modulated radiotherapy (IMRT) is recommended to enhance precision. To minimize damage to normal tissues, deep inspiration breath-hold techniques are advised, especially in cases where vital structures are at risk.
In cases involving skin or superficial margins, the use of a tissue-equivalent bolus is recommended to ensure adequate dose delivery; however, routine use of bolus material is not advised across all cases.
The guidelines also underline that the benefits of PMRT must be balanced with individual patient characteristics and personal preferences, underscoring the importance of personalized, evidence-based decision-making. Overall, these guidelines aim to improve clinical outcomes and tailor therapy to each patient’s unique disease profile.
For further details, the guidelines and clinical recommendations can be accessed in the September 2025 issue of Practical Radiation Oncology. These updates support clinicians in making informed choices while advancing breast cancer treatment protocols.
source: https://medicalxpress.com/news/2025-09-guidelines-postmastectomy-therapy.html
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
Advancements in Gene-Editing Offer Hope for Late-Onset Tay-Sachs Disease Treatment
Researchers at NIH have made groundbreaking progress in developing a gene-editing therapy that could delay or prevent symptoms of late-onset Tay-Sachs disease, offering hope for affected individuals worldwide.
AI-Generated Genomes Promise to Boost Precision Medicine While Protecting Patient Privacy
Researchers have developed AI-generated synthetic cancer genomes that enhance diagnostic tools and protect patient privacy. These realistic genomes enable better benchmarking and innovation in precision oncology.
Is It Still Worth Getting a Flu Shot in 2025?
Learn why getting a flu shot in 2025 is still highly recommended, even as the season peaks and extends. Protect yourself and those around you by understanding vaccine effectiveness, safety, and timing.
White House Report Attributes Youth Health Decline to Toxins, Diet, and Screen Time
A White House report highlights environmental toxins, poor nutrition, and excessive screen time as key factors contributing to the decline in children's health, calling for urgent action to improve youth wellness.