Combination of Aumolertinib and Chemotherapy Extends Progression-Free Survival in NSCLC Patients
A recent Phase III clinical trial reveals that combining aumolertinib with chemotherapy significantly improves progression-free survival in patients with advanced non-small cell lung cancer, offering new hope for personalized treatment strategies.
Recent clinical trial results have demonstrated that combining aumolertinib with platinum-based chemotherapy significantly enhances progression-free survival (PFS) in patients with advanced or metastatic non-small cell lung cancer (NSCLC) harboring EGFR sensitizing mutations along with tumor suppressor gene mutations. The Phase III ACROSS 2 trial, presented at the 2025 World Conference on Lung Cancer by Dr. Jie Wang from the National Cancer Center in China, compared the efficacy of the combination therapy versus aumolertinib alone.
Aumolertinib, an oral third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has been used to target EGFR-mutated NSCLC. Patients with additional mutations, which often result in a poorer prognosis, previously had limited effective treatment options. The ACROSS 2 trial was the first large-scale, global randomized study to investigate whether adding chemotherapy could improve outcomes in this specific subgroup.
The study enrolled patients with confirmed stage IIIB–IV NSCLC, suitable performance status, and specific mutation profiles. Participants were randomized to receive either a combination of aumolertinib at 110 mg daily with carboplatin (AUC=5) and pemetrexed (500 mg/m²) every three weeks, or aumolertinib alone, until disease progression. Stratification was based on mutation type and presence of brain metastases.
Results showed a median PFS of approximately 19.78 months for the combination therapy, compared to 16.53 months for monotherapy, with a hazard ratio of 0.55, indicating a substantial benefit of the combined approach. The trial also found that safety profiles remained consistent across groups, with common side effects including blood count reductions, anemia, liver enzyme increases, nausea, and rash. Importantly, the addition of chemotherapy did not introduce new safety concerns.
These findings suggest that incorporating chemotherapy with aumolertinib could become a new standard for treating NSCLC patients with complex mutation profiles, offering them greater disease control and improved prognosis. Further follow-up is needed to evaluate overall survival data, but current results are promising for advancing personalized lung cancer treatment.
Source: https://medicalxpress.com/news/2025-09-aumolertinib-chemotherapy-free-survival-nsclc.html
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
AI Technology Enables Early Detection of Surgical Site Infections via Patient Photos
Mayo Clinic researchers have developed an AI system that accurately detects surgical site infections from patient-submitted photos, promising faster and more efficient postoperative care. This innovative technology could transform wound monitoring and early infection detection.
Innovative Cell Cross-Talk Enhances CAR-T Therapy Against Glioblastoma
A novel cell cross-talk strategy boosts CAR-T therapy for glioblastoma by reprogramming the tumor microenvironment with targeted cytokine delivery, improving immune activation and survival in preclinical models.
Benzaldehyde Inhibits Pancreatic Cancer Spread by Disrupting Critical Protein Interactions
Scientists have discovered that benzaldehyde, a compound with a distinctive aroma, can hinder the spread of pancreatic cancer by disrupting key protein interactions, offering hope for overcoming treatment resistance.
