The Growing Interest in Microdosing Psychedelics: Beliefs versus Scientific Evidence

Microdosing involves taking very small amounts of psychedelic substances like psilocybin mushrooms or LSD, primarily to improve mental well-being. This practice has gained popularity among health enthusiasts who claim it helps reduce anxiety, stress, and depression, while enhancing creativity, joy, and a sense of connection. Unlike a full psychedelic trip, microdosing is done intermittently and with doses so low that visions or hallucinations are typically absent. Many users report feeling a general sense of well-being and better coping mechanisms, especially those with conditions like PTSD, as in the case of Marine veteran Matt Metzger who grows his own psilocybin mushrooms in Washington where decriminalization has taken place. Similarly, in Loveland, Colorado, microdosing is believed to improve parenting and creativity by fostering a healthier sense of presence.

However, scientific research into these claims is still in its infancy. Some studies suggest that the perceived benefits may be largely due to the placebo effect—where expectations influence outcomes. For instance, a notable study found that after four weeks, participants’ psychological measures improved regardless of whether they took actual microdoses or placebo capsules, indicating the potential influence of belief. Researchers also note that some small trials show brief boosts in mood and vitality among users with mild depression, but lasting effects on cognition and creativity remain unproven.

The legal landscape surrounding microdosing is evolving. While psilocybin remains illegal in most areas, states like Oregon and Colorado have begun to legalize supervised psychedelic therapy, and some cities have deprioritized enforcement against these substances. Despite the growing interest, experts caution about the lack of comprehensive long-term studies and warn against unregulated products potentially containing harmful substances. Support services like the Fireside Project have received numerous calls from individuals exploring microdosing.

Overall, while anecdotal reports are positive, scientific evidence remains preliminary. Enthusiasts are encouraged to approach microdosing with caution, aware of its unproven long-term effects, and to stay informed about ongoing research efforts. Studies are currently exploring microdosing's potential for severe depression and in cancer-related despair, but much remains to be understood about its true impact and therapeutic value.

Source: https://medicalxpress.com/news/2025-04-believers-microdosing-psychedelics-scientists.html