Study Finds LSD Can Reduce Anxiety Symptoms for Several Months

A recent study has shown that a single dose of LSD can significantly alleviate anxiety symptoms in individuals with moderate to severe anxiety, with effects lasting up to three months. The research, published on September 4, 2025, in the Journal of the American Medical Association (JAMA), involved nearly 200 patients who received various doses of LSD under professional supervision. Results indicated that those who received higher doses experienced a considerable reduction in anxiety scores at four weeks, with many continuing to see improvements at the 12-week mark. Notably, about 65% of patients on the most effective dose, 100 milligrams, remained in remission, highlighting the potential for lasting benefits. Lead researcher Dr. Maurizio Fava emphasized that some patients might require re-treatment, but the overall long-term impact is promising. Unlike typical psychedelic studies that incorporate extensive talk therapy, this trial focused solely on drug administration in a clinical setting, which helps to clarify the drug's direct effects. However, the study had limitations, including unblinding issues, as many participants correctly guessed their treatment, and some early dropouts narrowed the data pool. Common side effects included hallucinations, nausea, and headaches. Currently, MindMed is conducting larger, late-stage trials to confirm these findings and pursue FDA approval. The growing interest in psychedelics is driven by research exploring potential treatments for depression, PTSD, and anxiety, with the FDA granting breakthrough therapy status to several compounds, including LSD. Considering that nearly 3% of U.S. adults experience generalized anxiety disorder, these developments could lead to new therapeutic options beyond traditional treatments like psychotherapy and medications.