Innovative Wireless Neural Interface Enables Precise Deep Brain Drug Delivery
Researchers have developed a flexible, wireless neural interface capable of delivering drugs precisely to deep brain regions, offering new hope for treating neurological disorders.
A team of researchers has developed a groundbreaking implantable wireless neural interface that offers targeted drug delivery to deep brain regions. This advanced device integrates a micro-pump and microchannel system crafted from flexible materials, allowing for highly precise infusion at specific times and locations without the need for external equipment. Such technology could significantly improve treatment options for intractable neurological conditions like Parkinson's disease and epilepsy.
The wireless system is capable of controlling drug administration in real-time through a wireless control module, which adjusts infusion rates and dosages remotely. This flexibility minimizes the invasiveness and limitations associated with traditional infusion devices, which rely on external pumps and tubing that restrict patient mobility.
The device mimics gastrointestinal peristalsis using a micro-pump and features an inclined nozzle-diffuser channel to prevent backflow, ensuring accurate and safe drug delivery. Fabricated from soft, biocompatible materials, the system was tested on brain phantoms (agarose gel), demonstrating constant drug infusion without backflow and precise wireless control of infusion parameters.
Published in npj Flexible Electronics, the research was led by Professor Kyung-In Jang from DGIST’s Department of Robotics and Mechatronics Engineering. The team envisions future enhancements including integration of electrodes and sensors for real-time brain monitoring and automated drug administration, paving the way for personalized neurological treatment systems.
This innovation addresses the significant challenge posed by the blood-brain barrier, which often hampers drug delivery to targeted brain regions. By enabling minimally invasive, wireless, and precise drug infusion, this technology could transform treatment approaches for complex brain disorders. The team plans to evaluate long-term stability and move toward clinical applications to improve patient outcomes.
Source: https://medicalxpress.com/news/2025-09-wireless-neural-interface-drug-delivery.html
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