A Vitamin B1 Derivative Boosts Wakefulness and Physical Activity, Study Shows

Researchers at the University of Tsukuba have discovered that a modified form of vitamin B1, known as tetrahydrofurfuryl disulfide (TTFD), can significantly promote arousal and increase physical activity. TTFD is a chemically enhanced derivative of thiamine (vitamin B1) designed for better absorption and tissue penetration, and it has been traditionally used to address thiamine deficiencies that led to conditions like beriberi during historical periods such as the Edo and Meiji eras.

In recent years, thiamine derivatives have become popular as nutritional supplements to support daily energy requirements, especially in modern societies where deficiency is less common. However, ongoing research is exploring their potential effects on brain function and overall vitality.

Previous studies by the team revealed that TTFD elevates dopamine levels in the medial prefrontal cortex of rats, facilitating enhanced motivation and activity. This increase in dopamine, a crucial neurotransmitter involved in arousal and motivation, is associated with activation of brain regions including the ventral tegmental area and the locus coeruleus.

To investigate whether TTFD could actively promote wakefulness, scientists administered the compound intraperitoneally to rat subjects and monitored changes in sleep-wake patterns and physical activity through EEG and electromyography analyses. Their findings demonstrated that TTFD significantly boosted wakefulness and activity levels, suggesting its promising role in enhancing daily vitality.

The study, published in The Journal of Physiological Sciences, points to the potential of TTFD as a tool for improving alertness and physical performance. Future research aims to uncover the neural mechanisms behind these effects, possibly paving the way for new approaches to manage fatigue and promote mental clarity.

This breakthrough aligns with the ongoing interest in nutraceutical interventions aimed at optimizing brain function and energy levels. Source: https://medicalxpress.com/news/2025-05-vitamin-b1-derivative.html