Teen Risks Persist as Social Media Challenges Drive Dangerous Misuse of Over-the-Counter Antihistamines

Recent research highlights a concerning trend among adolescents and young adults engaging in misuse of common over-the-counter antihistamines, particularly diphenhydramine, influenced by social media challenges. Presented at the American Academy of Pediatrics 2025 Conference & Exhibition, these activities pose serious health risks, including heart arrhythmias, seizures, coma, and even death.

The misuse is often fueled by viral social media phenomena such as the notorious "Benadryl Challenge" on TikTok. This challenge encourages teens to consume large quantities of allergy medication containing diphenhydramine to induce hallucinations and a high, disregarding the dangers involved. Pediatric resident physician Noelia Swymeler from the University of Oklahoma emphasized that these trends continue to rise years after their initial virality, demonstrating the powerful impact of social media on risky behavior.

Diphenhydramine, a first-generation antihistamine, when misused, can lead to severe toxicity and adverse outcomes. Experts alert parents, healthcare professionals, and social media platforms to remain vigilant, as harmful videos and challenges remain accessible online long after being posted. It is recommended that families store medications securely to prevent unauthorized access and misuse.

Swymeler advocates for increased education, robust safety measures, and heightened awareness to prevent teens from harming themselves through easily accessible medications. This ongoing issue underscores the importance of proactive measures to safeguard youth health in the digital age.

Source: https://medicalxpress.com/news/2025-09-social-media-linked-dangerous-misuse.html