Artificial Sweetener Sucralose May Reduce Effectiveness of Cancer Immunotherapy
Emerging research indicates that the artificial sweetener sucralose may reduce the effectiveness of cancer immunotherapy by altering gut microbiota and immune cell function. Learn what this means for cancer patients and their dietary choices.
Artificial Sweetener Sucralose and Cancer Immunotherapy
Artificial sweeteners, commonly used to reduce calorie intake in diet foods and beverages, have raised health concerns, including links to gastrointestinal issues, metabolic problems, and potential cancer risks. Recent research suggests that sucralose, one of the most popular sweeteners, may impair cancer immunotherapy effectiveness.
Studies demonstrate that sucralose alters gut microbiota, decreasing bacteria that produce the amino acid arginine, crucial for immune cells to attack cancer. Experiments in mice showed increased tumor growth and diminished T-cell activity when fed high sucralose levels. Additionally, human studies linked high sucralose intake with poorer responses to immunotherapy in lung and melanoma cancers.
Experts warn that consuming large quantities of sucralose, such as through diet sodas, could compromise cancer treatments. Supplementing with arginine or citrulline might counteract these effects, offering a potential strategy for patients. Researchers advocate for further investigations but currently recommend minimizing artificial sweetener intake during immunotherapy treatments.
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