Research Finds Fewer Melanoma Cases in People with Multiple Tattoos

A recent study conducted by researchers at Huntsman Cancer Institute, University of Utah, suggests that individuals who have undergone multiple tattoo sessions may have a reduced risk of developing melanoma, a serious form of skin cancer. The research, led by Jennifer Doherty, Ph.D., MS, involved analyzing data from approximately 7,000 people in Utah. The findings revealed that those with two or more tattoos showed a decreased likelihood of developing both invasive and in situ melanoma—the latter being a type where cancer cells remain on the skin's surface and can be more easily treated.

Interestingly, the study also found that individuals with only one tattoo session were more prone to melanoma, especially the in situ type. This unexpected result has prompted scientists to consider various explanations, including behavioral factors or potential immune responses triggered by tattooing.

The researchers hypothesized initially that tattoos might increase cancer risk due to carcinogens present in tattoo inks, such as metals and chemicals, which can break down over time, possibly leading to new carcinogens. Additionally, tattoos induce inflammatory responses, which are often linked to cancer development. However, the observed protective effect in individuals with multiple tattoos was surprising.

Rachel McCarty, Ph.D., a postdoctoral scientist involved in the study, explained that while tattoos are increasingly popular—about one-third of American adults have tattoos—their impact on cancer risk is not well understood. It’s possible that people with multiple tattoos are more vigilant about sun protection or that tattoos serve as physical barriers against ultraviolet radiation or immune elements that could trigger tumor formation.

The team speculates that immune responses to tattoo pigments might play a role in lowering melanoma risk, but more research is necessary to understand this connection fully. They emphasize that individuals with tattoos should still prioritize skin protection, such as using sunscreen, to prevent tattoo fading or potential skin damage.

While the study indicates a potential protective effect against melanoma, it is not yet clear whether tattoos influence the risk of other cancers. Prior studies suggest possible associations with certain blood cancers. Overall, these findings could enhance melanoma prevention strategies, especially in regions like the American Mountain West, where melanoma rates are high.

The study highlights the importance of understanding environmental and lifestyle factors, like tattooing, that may influence cancer risk, paving the way for more personalized skin cancer prevention and education efforts in the future.

Source: https://medicalxpress.com/news/2025-09-melanoma-common-individuals-tattoos.html