Study Confirms COVID-19 Vaccinations Are Metabolically Safe

Recent research conducted by Murdoch University's Australian National Phenome Center provides reassuring evidence that COVID-19 vaccines are metabolically safe, even after multiple doses. Published in the Journal of Molecular Medicine, the study tracked 167 metabolic markers in 33 participants over a period of 480 days, spanning 28 different time points following vaccination.

Lead researcher Associate Professor Ruey Leng Loo explained that their findings revealed no significant alterations in vital health indicators such as inflammatory markers, cardiovascular risk factors, lipoproteins, amino acids, or molecules involved in energy pathways. The stability of these markers suggests that vaccination does not induce major metabolic shifts.

The study included a comparison between vaccinated individuals and a control group with no prior COVID-19 infection, as well as those who experienced mild cases. The results showed that the metabolic profiles of vaccinated persons closely resembled those of the controls, affirming that the vaccines do not provoke adverse metabolic responses.

An isolated observation was a slight increase in the inflammation-related marker Chemokine IP10 after the third dose, but levels remained within normal ranges and returned to baseline before subsequent doses. While mild infection can cause notable metabolic changes, the minor fluctuations seen post-vaccination highlight the safety and biological stability associated with COVID-19 immunizations.

Associate Professor Loo emphasized that these positive results should increase confidence among those hesitant about multiple vaccine doses. However, she also noted the need for further research involving larger and more diverse populations to confirm these findings.

Overall, this study offers significant reassurance that COVID-19 vaccines are safe from a metabolic standpoint, countering misconceptions and supporting ongoing vaccination efforts.

Source: https://medicalxpress.com/news/2025-04-covid-vaccinations-metabolically-safe.html