Potential Increased Stroke Risk After Hysterectomy with Bilateral Oophorectomy

Recent research indicates that women who undergo hysterectomy combined with bilateral oophorectomy may face a higher risk of stroke later in life. The study, based on data from the National Health and Nutrition Examination Survey (NHANES) involving over 21,000 women, followed participants for an average of 8.3 years and documented 193 stroke-related deaths. The results showed that women who had both a hysterectomy and bilateral oophorectomy had an 18% increased risk of stroke, whereas those with hysterectomy alone had a 5% increased risk. However, hysterectomy without oophorectomy did not appear to significantly raise stroke risk.

The impact of these surgeries on hormonal levels, particularly estrogen, is a key factor. Hysterectomy can lead to decreased ovarian steroid production and may precipitate earlier menopause. Oophorectomy can reduce premenopausal serum estradiol by up to 80%, significantly decreasing estrogen and androgens, which are associated with vascular health.

Despite previous studies with mixed findings, the latest research emphasizes that the type of surgery and the presence or absence of bilateral oophorectomy influence long-term cardiovascular risks. The findings suggest a need for careful assessment and discussion of potential long-term health consequences when considering these procedures. Experts recommend more extensive studies to better understand how factors like age at surgery, surgical techniques, and menopause status may modify the associated risks. Ultimately, this evidence underscores the importance of monitoring cardiovascular health and adopting risk reduction strategies for women who undergo hysterectomy and/or oophorectomy.

Source: https://medicalxpress.com/news/2025-09-hysterectomy-bilateral-oophorectomy.html