'Single shot' malaria vaccine delivery system could transform global immunization

'Single shot' vaccine delivery technology developed by researchers at the University of Oxford promises to revolutionize immunization efforts worldwide. Using programmable microcapsules, this innovative system can deliver both the initial and booster doses of a vaccine in a single injection, potentially eliminating the need for multiple clinic visits. In preclinical trials, such as with the R21 malaria vaccine, this approach has demonstrated protection levels comparable to traditional multi-dose regimens, making it especially valuable for areas with limited healthcare access.

The microcapsules are created using a patented chip-based microfluidic system that produces biodegradable polymer shells capable of controlled, timed release of the booster dose weeks or months post-injection. This breakthrough could address one of the most significant obstacles in global immunization: ensuring recipients return for follow-up doses. The technology is scalable and compatible with current pharmaceutical manufacturing processes, enhancing its potential for rapid deployment.

According to lead researcher Romain Guyon, the system offers a scalable, injectable, and programmable solution that can be adapted for various vaccines requiring multiple doses. The team is now preparing for early human trials, aiming to adapt the manufacturing process for clinical use and expand the technology's applications. Experts highlight that successful development could substantially impact vaccination campaigns, reducing logistical challenges, and ensuring more children and adults are fully immunized, particularly where healthcare access is limited.

Published in Science Translational Medicine, this research opens new avenues for more effective and simpler vaccination strategies, with the potential to significantly decrease preventable disease burdens globally.

Source: https://medicalxpress.com/news/2025-06-shot-malaria-vaccine-delivery-global.html