Link Between Severe Pregnancy Nausea and Increased Mental Health Risks

A comprehensive study published in The Lancet Obstetrics, Gynaecology, & Women's Health has revealed that women experiencing severe pregnancy sickness, specifically hyperemesis gravidarum (HG), face a significantly higher risk of developing various mental health conditions. The largest investigation to date involved over 476,000 pregnant women from 135 healthcare providers worldwide, highlighting that the mental health risks increase by over 50% for numerous neuropsychiatric disorders.

Hyperemesis gravidarum affects up to 3.6% of all pregnancies and is characterized by intense nausea and vomiting, often leading to dehydration and weight loss. The condition commonly results in hospitalizations during the first trimester, with many cases resolving by the second trimester. Women with HG often experience anxiety, social isolation, and concerns about their ability to manage pregnancy, contributing to mental health challenges such as depression, anxiety, and trauma-related disorders.

The study identified that women with HG are at elevated risk for conditions including post-partum psychosis, post-traumatic stress disorder, eating disorders, depression (especially post-partum depression), Wernicke's encephalopathy, and refeeding syndrome. Remarkably, the research found that more severe metabolic disturbances in HG, such as dehydration and electrolyte imbalances, were associated with a lower risk of depression, emphasizing that mental health risks are present independently of HG severity.

Experts stress the importance of integrated care approaches addressing both physical symptoms and mental health needs. Dr. Hamilton Morrin from King's College London explained that HG's profound impact extends beyond physical discomfort, necessitating urgent referral to mental health services. Senior author Dr. Thomas Pollak emphasized that acknowledging and treating these psychiatric risks early can improve outcomes for mothers and their babies.

This study underscores that mental health considerations should be an integral part of managing hyperemesis gravidarum, advocating for comprehensive screening and support throughout pregnancy.

Source: https://medicalxpress.com/news/2025-09-severe-pregnancy-sickness-mental-health.html