Emerging Public Health Threat: Rising Rates of Cardiovascular-Kidney-Metabolic Syndrome in the US

A recent comprehensive study reveals that the United States is experiencing an alarming increase in the prevalence of cardiovascular-kidney-metabolic (CKM) syndrome, a complex condition linked to interconnected problems like obesity, diabetes, kidney disease, and cardiovascular issues. First identified by the American Heart Association in 2023, CKM syndrome now affects approximately 80% of the American population, with no state showing a decline over the past decade.

Using self-reported data from the CDC’s Behavioral Risk Factors Surveillance System from 2011 to 2023, researchers led by Tarang Parekh at the University of Delaware analyzed state-level prevalence rates. Their findings show that West Virginia has the highest prevalence, affecting nearly 87% of its residents, with Delaware and Colorado also experiencing significant rates. The Southeast and Midwest remain the hardest hit regions.

CKM develops progressively through multiple stages. Initially, individuals may be overweight or prediabetic, progressing to stages involving kidney impairment, hypertension, high cholesterol, and diabetes. The most severe stage results in clinical cardiovascular disease such as heart failure, stroke, or kidney failure. The study indicates that nearly half of the states have seen increases in early to mid-stage CKM conditions, while the most severe stage has seen mixed trends, with Minnesota recording a concerning rise.

Experts emphasize that early detection and lifestyle modifications are critical in preventing or slowing disease progression. Routine health screenings that monitor blood pressure, weight, and blood sugar levels are essential, alongside public education about the risks of CKM syndrome. Currently, efforts are underway through the American Heart Association’s pilot CKM health initiative, which aims to deliver holistic care and improve diagnosis in targeted regions, with plans to expand nationwide.

The initiative convenes multidisciplinary healthcare providers to address all facets of the syndrome comprehensively. Researchers also plan to utilize electronic health records and machine learning tools to better predict and manage CKM progression, hoping to reduce future cardiovascular and kidney-related complications.

Understanding the interconnected nature of these health issues highlights the importance of integrated prevention strategies, advocating for broader community and healthcare system engagement to curb this growing epidemic.