Innovative Pulsating Microneedles Offer Painless Transdermal Drug Delivery

Recent advancements in microneedle technology have led to the development of pulsating microneedles that provide a virtually pain-free alternative to traditional injections. Created by a collaborative team from Griffith University and the University of Newcastle, these microneedles are designed to be less than 1 millimeter long, enabling painless penetration of the skin's outer layer for medication delivery.

The innovative fabrication process, known as the "pulsating in situ dried electro stretching" (PIDES) technique, utilizes a pulsed electro-hydrodynamic force between metallic plates to stretch and shape polymer droplets into fine, conical microneedles. As the solvent evaporates, the polymer solidifies into a sharp, rigid tip capable of piercing the skin without causing discomfort.

Extensive testing on agarose gel and pig skin confirmed the mechanical strength of these microneedles and their ability to effectively penetrate the skin. Additionally, the team successfully encapsulated curcumin, a model compound, demonstrating controlled, time-dependent drug release suitable for physiological conditions.

This manufacturing method simplifies production, reduces costs, and shows promise for scalable, high-quality microneedle fabrication. The researchers envision future developments including on-demand microneedle arrays to enhance precision and flexibility in drug delivery systems.

Overall, this novel approach could pave the way for more accessible, patient-friendly transdermal medication administration, offering a painless alternative to conventional injections and broadening the scope of drug delivery options.

Source: https://medicalxpress.com/news/2025-07-pulsating-microneedles-pain-free-alternative.html