Newly Discovered Protein Facilitates TBE Virus Entry into Brain Cells
Scientists have discovered that the protein LRP8 on cell surfaces is essential for the tick-borne encephalitis (TBE) virus to infect human brain cells, opening new possibilities for targeted treatments.
Researchers from the Karolinska Institutet and international partners have identified a key protein on cell surfaces that is essential for the tick-borne encephalitis (TBE) virus to infect human cells. The study, published in Nature, reveals that the protein LRP8 acts as a critical receptor enabling the virus to cross cellular barriers and invade brain cells. This breakthrough was achieved by exposing a vast library of genetically modified cells to the virus, pinpointing LRP8 as the crucial factor; cells lacking this protein survived infection, indicating its vital role. LRP8 is highly expressed in brain tissue, making it especially relevant to the neurological impacts of TBE.
The virus is predominantly transmitted through tick bites, which can lead to severe neurological diseases. Its prevalence is increasing across Europe and Asia, paralleling the rise in tick populations. Despite the availability of a vaccine, there are no targeted treatments for individuals already infected. As a biosafety level 4 pathogen, TBE requires strict laboratory protocols.
The study demonstrated that the TBE virus’s surface protein specifically binds to LRP8, exploiting this receptor to gain entry into cells—particularly neurons in the brain. Understanding this mechanism opens new avenues for developing antiviral drugs that block this interaction, potentially preventing infection or reducing its severity. Notably, this research marks the first identification of a direct host cell receptor for a flavivirus, a family of viruses that includes yellow fever, dengue, and Japanese encephalitis, which are typically transmitted by mosquitoes or ticks.
Future research aims to understand how LRP8 facilitates the virus’s pathogenic effects within the brain’s neuronal network. The discovery offers hope for innovative therapies that can inhibit the initial stages of TBE virus infection, significantly impacting public health in endemic areas.
Source: https://medicalxpress.com/news/2025-09-key-protein-borne-encephalitis-revealed.html
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
New Insights into Molecular Causes of Cystic Fibrosis Drug Resistance
Recent research uncovers the molecular mechanisms behind cystic fibrosis drug resistance, paving the way for personalized treatments tailored to individual CFTR gene variants. Discover how scientists are working to improve outcomes for resistant CF patients.
What Ever-Growing Incisors Reveal About Genetic Disorders
A groundbreaking study reveals how the study of ever-growing incisors in rodents can enhance our understanding of genetic craniofacial disorders and dental development, offering potential new avenues for diagnosis and treatment.
Innovative Gene Therapy Targets Virus-Linked Cancers Using Genetic 'Trojan Horse'
A novel gene therapy utilizing a genetic 'Trojan horse' shows promise in selectively destroying virus-infected cancer cells, offering safer and more targeted treatment options for KSHV-associated cancers.
Innovative AI-Driven Development of Broad-Spectrum Coronavirus Antiviral Drugs
Harvard scientists utilize AI-enabled modeling to develop broad-spectrum antiviral drugs targeting coronaviruses, promising rapid and effective pandemic responses.