Investigating Probiotics to Support Maternal Gut Health

A recent study conducted by the Burnet Institute highlights the potential role of probiotics in improving gut health among pregnant women. The research aims to fill the current gap in clinical guidance for probiotic use during pregnancy, especially concerning environmental enteric dysfunction (EED). EED is a condition that predominantly affects children in low-resource settings, but it also impacts pregnant women by impairing nutrient absorption. This can lead to complications like anemia and hinder fetal growth, despite supplementation efforts.

Currently, there are no globally accepted treatments specifically targeting EED, and definitions for effective probiotic interventions in pregnant women are lacking. To address this, the study developed a comprehensive target product profile (TPP) for probiotics that could enhance maternal health outcomes. Published in PLOS One, this profile outlines necessary clinical and implementation standards for probiotic products, as well as analyzing potential candidates for future research.

Burnet research officer Kate Mills emphasized the importance of this work in accelerating research efforts. While many women already use probiotics during pregnancy, there is no structured framework guiding optimal candidate selection. The study recommends that probiotic interventions should ideally target populations broadly, especially in settings where EED prevalence is highest, and should prioritize affordability and stability without refrigerant requirements.

The research identified one high-potential and two medium-potential probiotic candidates currently in development. Though promising, further evidence is necessary to establish robust guidelines. The goal is to develop safe, effective, and accessible probiotic treatments that improve nutritional absorption and overall maternal health—especially in resource-limited areas.

This initiative aims to guide future clinical trials and product development, ultimately enhancing maternal and perinatal health worldwide.