Potential of Psilocybin ('Magic Mushrooms') to Enhance Motor Function and Mood in Parkinson's Disease Patients

Recent research from the University of California, San Francisco explores the promising effects of psilocybin, a compound derived from certain mushrooms, in managing symptoms of Parkinson's disease beyond traditional treatments. Recognized primarily for its role in treating depression and anxiety, psilocybin is now being investigated for its potential to improve motor functions and mood disturbances commonly experienced by Parkinson's patients.

In a pioneering pilot study, UCSF researchers administered controlled doses of psilocybin to a small group of participants with mild to moderate Parkinson's. The study involved seven men and five women who received a 10 mg dose initially, followed by a 25 mg dose two weeks later. Participants engaged in psychotherapy sessions surrounding the drug administration, with evaluations conducted over subsequent weeks.

Results indicated that the participants tolerated the treatment well, with no serious adverse effects or worsening of symptoms. Remarkably, they exhibited significant, lasting improvements in mood, cognition, and motor symptoms that persisted for weeks post-treatment. Follow-ups three months after the sessions confirmed sustained mood enhancement. The improvements could be due to psilocybin's ability to promote neuroplasticity and reduce inflammation, potentially facilitating brain repair.

These findings are groundbreaking as they represent the first instance of a psychedelic being tested in patients with a neurodegenerative disease. The positive outcomes have spurred ongoing research, including a larger, multi-center trial at UCSF and Yale University, aiming to enroll 100 participants. This expanded study seeks to utilize neuroimaging and brain stimulation techniques to better understand how psilocybin influences neurodegeneration.

Parkinson's disease affects over one million Americans, characterized by symptoms such as tremors and difficulty walking. Often, psychological symptoms like anxiety and depression may predict physical decline more strongly than motor issues, yet standard medications frequently fall short in addressing these aspects.

The new research underscores the potential for psilocybin not only to alleviate mood and cognitive symptoms but also to provide benefits in motor functions—effects that could modify the disease trajectory. While still in early stages, this work offers hope for new therapeutic avenues that could transform healthcare approaches for neurodegenerative disorders.

source: https://medicalxpress.com/news/2025-04-magic-mushrooms-motor-function-mood.html