The Link Between Physical Performance, Cognitive Function, and Functional Capacity in Multiple Sclerosis Patients

Recent research by the University of Eastern Finland highlights the significant connection between physical performance, cognitive abilities, and overall functional capacity in individuals with relapsing-remitting multiple sclerosis (MS). The study demonstrates that maintaining good physical performance correlates with enhanced cognitive skills and better functional status. Utilizing diverse measurement methods—including the six-minute walk test for physical capacity, accelerometers for physical activity, and assessments like SDMT and PASAT for cognition—the researchers found that patients with higher disability levels (EDSS over 2.5) exhibited notably weaker cognitive functions, especially in information processing tasks. Notably, better walking test results were linked to improved cognition among those with moderate disability (EDSS 3–5.5). In healthy controls, higher daily physical activity was associated with better cognitive performance, though this pattern was not evident in the MS patient group. These findings underscore the importance of regular physical activity and cognitive assessments in managing MS, as cognitive impairment substantially affects disability and societal participation, including work ability. The study advocates for routine cognitive testing as part of comprehensive MS management and encourages further research into the complex relationship between cognition, functional capacity, and physical fitness across different MS subtypes.