New Research Suggests Omega-3 Fats Might Increase Certain Inflammatory Markers

Recent scientific findings have challenged the common assumption that omega-3 fatty acids universally reduce inflammation in the body. A comprehensive study conducted by researchers at the University of Bristol and published in the International Journal of Epidemiology reveals that higher levels of omega-3 fats, which are abundant in oily fish and often consumed through supplements for their supposed anti-inflammatory benefits, may actually be associated with an increase in specific inflammatory biomarkers.

Dr. Daisy Crick, a key researcher involved in the study, explained that the traditional view of omega-3 as anti-inflammatory and omega-6 as pro-inflammatory is more complex than previously thought. The research utilized data from the Avon Longitudinal Study of Parents and Children, tracking participants over nearly three decades. They measured inflammation using blood biomarkers and observed that elevated omega-3 levels correlated with increased inflammation.

Furthermore, the study found that a higher ratio of omega-6 to omega-3 fats was linked to higher levels of inflammatory markers, suggesting that an imbalance favoring omega-6 might promote inflammation. These findings were validated using the extensive UK Biobank dataset and Mendelian randomization analysis, a method that employs genetics to explore causal relationships.

The implications of this research question the conventional dietary recommendations that emphasize omega-3 intake for reducing inflammation-related health risks. Dr. Crick emphasizes that the relationship between dietary fatty acids and inflammation is intricate and highlights the importance of considering the overall balance or ratio of omega-6 to omega-3 fats in dietary planning.

While omega-3 fats have long been advocated for their anti-inflammatory properties, these new insights suggest that their effects may not be universally beneficial and could vary depending on individual biological factors and dietary context. Further research is necessary to fully understand the interactions among fatty acids and inflammation.

For more detailed information, refer to the original publication in the International Journal of Epidemiology or visit the source at https://medicalxpress.com/news/2025-06-omega-fats-inflammation-indicators-body.html.