Objective Insights into the Effects of Hyaluronic Acid Fillers through Volumetric Study

A recent comprehensive study has employed advanced 3D imaging technology to evaluate the impact of hyaluronic acid (HA) fillers on facial volume restoration. Published in the October issue of Plastic and Reconstructive Surgery, this research provides valuable quantitative data on how HA fillers influence facial aesthetics over time.

The study involved 101 women aged 40 to 65, who received HA filler injections across various facial regions. Utilizing the Vectra M3 3D imaging system, researchers captured facial scans immediately before treatment, right after, and during follow-up periods of two to twelve weeks. These scans allowed precise measurement of volumetric changes in eight targeted facial areas.

Key findings include an immediate volumetric increase of 125% to 56% post-injection, with the effects diminishing as initial swelling subsided. At two weeks, the effective volume (EV) was approximately 90% in the lower and midface regions and 70% in the lips. By the 12-week mark, volume retention varied across regions: about 66% overall, with the midface maintaining the highest at 79%, the upper perioral area at 63%, and lips at 37%. These results underscore the regional differences in volume loss, influenced by facial movement and specific filler properties.

Patient-reported outcomes, assessed via the validated FACE-Q questionnaire, demonstrated significant improvements in appearance, psychological well-being, and social confidence. Notably, the study reinforced that patient satisfaction persists at a minimum of 12 weeks post-treatment. The outcomes were also affected by individual factors such as age, smoking history, and body mass index, highlighting the importance of personalized treatment planning.

Senior author Dr. Ivona Percec from the University of Pennsylvania emphasized that these objective measurements enhance understanding of HA fillers’ effectiveness. The research indicates that the initial two-week measurements probably reflect the final clinical volume, influenced by physical properties of the filler and facial dynamics. The study advocates for clinicians to incorporate these objective data points into consultations, to better set patient expectations and optimize results.

Overall, this research offers a clearer, data-driven perspective on how HA fillers impact facial volume immediately and over the long term, reinforcing their role in minimally invasive facial rejuvenation procedures.