Neutrophil-Tumor Cell Interaction as a Potential Target and Biomarker in Advanced Breast Cancer

Recent research conducted by scientists at Tel Aviv University's Gray Faculty of Medical & Health Sciences has uncovered vital insights into the tumor microenvironment in advanced breast cancer stages. The study highlights the significant role of immune cells known as neutrophils, which are recruited by the tumor to support its growth and spread. Using advanced single-cell RNA sequencing techniques, the researchers analyzed breast tissue samples from mice at various developmental stages, including healthy and cancerous states.

The findings reveal that in advanced disease, neutrophils and endothelial cells are predominant in the tumor tissue, with neutrophils closely interacting with cancer cells. These immune cells are stimulated by cancer cells to produce substances that enhance tumor invasion, metastasis, and the development of blood vessels that nourish the tumor. Interfering with neutrophil activity in mouse models led to a reduction in tumor proliferation and blood vessel formation, underscoring their importance in disease progression.

Furthermore, in patients with late-stage breast cancer, higher expression of molecular signatures associated with neutrophils correlated with poorer survival rates. These results suggest that neutrophils are not only key players in tumor development but also promising targets for new therapeutic interventions and potential biomarkers for disease advancement.

Led by Dr. Sandra Camargo and her team, this groundbreaking study provides a deeper understanding of cell-to-cell communication mechanisms within the tumor microenvironment. It points to the possibility of developing drugs that specifically target neutrophil-tumor interactions, thereby offering new hope for more effective breast cancer treatments and improved diagnostic tools.

This research was published in Nature Cancer and emphasizes the importance of exploring immune cell dynamics to combat cancer more effectively.