Lactate IV Infusion Mimics Exercise-Induced Brain Benefits by Triggering Brain-Derived Neurotrophic Factor Release

Science confirms that physical exercise benefits the brain by enhancing blood flow, reducing stress hormones, and promoting the release of 'feel-good' endorphins. A key player in these benefits is Brain-Derived Neurotrophic Factor (BDNF), a protein produced by the liver, brain, muscles, and fat tissue, which supports nerve cell growth, survival, and maintenance.

Recent research has shed light on the role of lactate, a by-product generated during high-intensity exercise, in this process. Elevated blood lactate levels have been associated with increased BDNF activity in the brain, contributing to improved brain health and cognitive functions.

A groundbreaking study published in Frontiers in Cellular Neuroscience investigated whether administering lactate directly into the bloodstream could replicate the neurological benefits of exercise. The study involved 12 healthy volunteers aged between 20 and 40, who underwent randomized crossover testing. Each participant received a one-hour intravenous infusion of sodium lactate and, on a separate occasion, a saline solution as control, with sessions spaced by 7 to 30 days.

Blood samples collected throughout the experiment revealed that lactate levels peaked during infusion to values typical of intense exercise. Importantly, the levels of pro-BDNF, an active precursor to BDNF, increased within 15 minutes after the end of lactate infusion and remained elevated for two hours. However, levels of mature BDNF (mBDNF) did not change significantly during or after the infusion.

Muscle biopsies taken before and after infusions confirmed that lactate infusion primarily elevated pro-BDNF in the bloodstream without affecting muscle tissue or mature BDNF levels in blood plasma. These findings suggest that lactate can stimulate the release of pro-BDNF, which potentially contributes to brain health benefits associated with exercise.

While this discovery opens exciting avenues for neurological health interventions, experts caution against replacing exercise entirely with lactate infusions. The study's lead scientist, Dr. Marcus Moberg, emphasizes that high-intensity exercise remains crucial for optimal brain health, suggesting that periodic intense workouts could be beneficial, especially for aging populations.

Future research aims to explore pharmacological methods that harness lactate’s hormonal-like effects, which might lead to targeted therapies for individuals unable to engage in regular physical activity. Nonetheless, the current findings reinforce the importance of incorporating high-intensity exercise into wellness routines for cognitive benefits.

Source: https://medicalxpress.com/news/2025-09-lactate-iv-infusion-body-hormone.html