Klotho Protein: A Key to Promoting Healthy Aging and Longevity

A groundbreaking international study led by the Institut de Neurociències at the Autonomous University of Barcelona has revealed that elevating levels of the Klotho protein in mice can significantly extend lifespan and enhance both physical and cognitive functions related to aging.

As humans age, natural declines in muscle mass and bone density often lead to increased frailty and a higher risk of falls and injuries. Additionally, neurons in the brain tend to degenerate over time, contributing to cognitive decline and increasing the prevalence of neurodegenerative diseases such as Alzheimer's and Parkinson's. Given the challenges posed by an aging society, researchers are exploring ways to mitigate these effects.

The recent study published in Molecular Therapy demonstrates that increasing the secretion of the soluble form of Klotho (s-KL) through gene therapy can provide multiple health benefits in aged mice. The researchers treated young animals with viral vectors designed to boost s-KL production. When these mice reached approximately 70 human years of age, they exhibited improved muscle strength, larger muscle fibers, and reduced fibrosis, indicating healthier muscles. Bone health also improved, especially in females, with better preservation of marrow trabeculae, suggesting a potential protective effect against osteoporosis.

Within the brain, the treatment promoted the generation of new neurons and enhanced immune activity in the hippocampus, hinting at possible cognitive benefits and improved neurological resilience.

The method used involves delivering genetic material via viral vectors to allow the body's cells to produce more s-KL naturally. These vectors were administered both intravenously and directly into the brain, ensuring that brain cells also contributed to increased s-KL levels. Researchers note that newer viral vectors capable of crossing the blood-brain barrier with intravenous injection could make this approach safer and more feasible for human applications. Alternatively, direct delivery of purified Klotho protein is an option, but requires further development to optimize delivery and target specificity.

The research team has already patented the use of Klotho for cognitive disorders, and following their latest findings, they filed additional patents for therapies targeting bone, muscle deterioration, and longevity extension. The promising results suggest that, with effective delivery methods, s-KL could become a key component in strategies aimed at improving quality of life during aging.

Overall, this research underscores the potential of Klotho as a therapeutic target to promote healthy aging, reduce age-related decline, and potentially extend lifespan, contributing to healthier societies worldwide.

Source: https://medicalxpress.com/news/2025-05-klotho-protein-healthy-aging-longevity.html