Innovative Systems-Level Drug Design Promises More Effective Treatments for Aging and Chronic Diseases

Recent advancements in artificial intelligence have revolutionized drug discovery, especially in addressing the complex biology of aging. In a collaborative effort between Scripps Research and biotechnology firm Gero, researchers have developed a machine learning model capable of identifying compounds that target multiple biological pathways simultaneously—a strategy known as polypharmacology. Unlike traditional approaches that focus on single-target drugs, this system embraces the multifaceted nature of aging, which involves an intricate interplay of numerous biological processes.

In practical application, the model successfully screened compounds that extended the lifespan of Caenorhabditis elegans, a widely used model organism in aging studies. Impressively, over 75% of the compounds tested led to lifespan extension, with one increasing lifespan by up to 74%. Such results position these compounds among the most potent longevity interventions ever observed in this model.

Dr. Peter Fedichev, CEO of Gero, explained that conventional drug discovery tends to seek highly precise, single-target solutions. However, aging's systemic and intertwined nature calls for a different approach. The integration of AI allows for the design of multi-target drugs intentionally, overcoming previous limitations that regarded such compounds as too complex or risky to develop.

Dr. Michael Petrascheck from Scripps Research highlighted that this breakthrough demonstrates AI's capacity to tackle biological questions of extraordinary complexity, enabling the development of therapies that act across multiple systems. This shift toward systemic treatment models lays the groundwork for a new generation of therapeutics aimed at extending lifespan and managing age-related diseases, which often involve the decline of multiple biological functions.

Overall, these discoveries suggest that embracing polypharmacological strategies could significantly improve the efficacy of treatments for aging and associated chronic conditions, marking a pivotal step forward in personalized and systemic medicine.

Source: medicalxpress.com/news/2025-05-drug-effective-therapies-aging-chronic