Innovative Shampoo-Like Gel Could Help Preserve Hair During Chemotherapy

Researchers at Michigan State University have developed a novel shampoo-like hydrogel aimed at protecting hair follicles from damage during chemotherapy. Chemotherapy-induced hair loss can cause significant emotional, social, and professional distress among cancer patients. Currently, limited solutions, such as costly cold caps with potential side effects, are used to mitigate this issue.

The new hydrogel gel, which has the consistency of shampoo, is formulated to be applied to the scalp before starting chemotherapy. The gel contains the active ingredients lidocaine and adrenalone, which work to restrict blood flow around hair follicles. This reduction in blood flow limits the amount of chemotherapeutic drugs reaching the follicles, thereby helping to prevent hair loss.

A key feature of the gel is its temperature responsiveness: at body temperature, it adheres firmly to the scalp and hair, offering sustained protection. When exposed to cooler temperatures, it becomes more fluid and can be easily washed away. This innovative approach aims to provide a practical, non-invasive solution that can be easily used by patients.

The hydrogel's design leverages its water-absorbing capacity and ability to deliver drugs over long periods. Once applied, it remains on the scalp during chemotherapy circulation and prevents the drugs from damaging hair follicles. The research team is seeking funding to advance into clinical trials, with the ultimate goal of making this protective gel available for human use.

This development represents a significant step towards improving the quality of life for cancer patients, addressing an unmet need with a safe and potentially effective solution based on well-established materials. The findings have been detailed in a paper published in Biomaterials Advances.

Source: Medical Xpress