Innovative PET Imaging Technique Enables Simultaneous Visualization of Three Radiotracers

A groundbreaking advancement in positron emission tomography (PET) imaging has been introduced, allowing for the concurrent visualization of three different radiotracers within a single scan. Presented at the Society of Nuclear Medicine and Molecular Imaging 2025 Annual Meeting, this multiplexed PET technique marks a significant leap forward in molecular imaging. By leveraging recent advancements in radionuclide production, radiochemistry, and imaging technology, researchers have developed a method to distinguish and unmix signals from multiple isotopes simultaneously.

The study, led by scientists at Stanford University, demonstrates the use of a triple-coincidence PET approach that employs a specialized 3x3 grid phantom. In this setup, the system successfully differentiated signals from isotopes such as fluorine-18 (¹⁸F), copper-64 (⁶⁴Cu), iodine-124 (¹²⁴I), and cobalt-55 (⁵⁵Co). The process involved sorting photon coincidence data by photon count and energy, then applying scaling factors to accurately separate signals and generate clear images of each tracer.

This technology opens new avenues for imaging complex diseases like cancer, where multiple biomarkers need to be monitored simultaneously. The ability to capture comprehensive molecular profiles in a single session can greatly enhance diagnostic accuracy and therapeutic monitoring. Although currently in the experimental stage, future developments are focusing on refining quantitative analysis, improving correction techniques, and adapting hardware for clinical use. Experts suggest that with continued innovation and commercial support, triplexed PET could become a staple in medical imaging within the next five years.

Dr. Sarah Zou from Stanford emphasizes the potential impact of this technology: "Multiplexed PET offers a powerful tool for exploring biologically complex conditions, providing clinicians with richer information to guide treatment decisions." The achievement signals a promising step towards more integrated and informative molecular imaging protocols.

Source: https://medicalxpress.com/news/2025-06-advanced-pet-technique-simultaneous-imaging.html