Innovative Injectable Ocular Hydrogel Aids in Repair of Retinal and Optic Nerve Injuries

Recent advances in ophthalmic biomaterials have led to the development of a novel soft, injectable hydrogel designed specifically for retinal repair and optic nerve protection. This innovative material is based on gelatin modified with natural polyphenols, enhancing its antioxidative properties and ability to adhere to tissue surfaces within the eye. Its high transparency and biocompatibility make it suitable for injection into the fragile inner eye environment without causing significant disturbance.

The hydrogel works by creating a supportive microenvironment that counters oxidative stress and inflammation—major factors in retinal degeneration and optic neuropathies. Laboratory studies involving animals have confirmed the safety and effectiveness of this hydrogel, demonstrating preserved retinal architecture and decreased cellular damage following injection.

Furthermore, this platform provides a promising scaffold for the delivery of stem cells, opening new avenues in regenerative medicine for retinal tissues. The research team from National Taiwan University highlights the potential of this material to serve as both a therapeutic agent and a tissue engineering scaffold, which could revolutionize treatments for retinal diseases and optic nerve injuries.

The study was published in Advanced Healthcare Materials and suggests that such injectable hydrogels could become an essential component of minimally invasive ophthalmologic therapies, offering new hope for patients suffering from degenerative retinal conditions and optic nerve damages.

source: https://medicalxpress.com/news/2025-07-soft-ocular-material-optic-neuropathy.html