New Research Finds One in Twelve Patients with Multiple Cancers Have Inherited Genetic Risks

Recent research has uncovered that approximately 1 in 12 individuals diagnosed with two or more different types of cancer carry inherited mutations in known cancer risk genes. This significant finding suggests that genetic predisposition plays a more prominent role in multiple cancer cases than previously understood. The study, conducted using data from the UK Biobank, analyzed 96 established cancer predisposition genes across 11 common cancers, including prominent genes like BRCA1 and BRCA2. Notably, 8.36% of people with multiple cancers harbored rare pathogenic variants in these genes, with associations identified between BRCA2 and cancers such as bladder and lung cancer—beyond the traditional links. This large-scale, population-based study indicates that inherited genetic risks are more widespread than previously thought, especially in individuals with multiple cancer diagnoses who are not usually subjected to routine genetic testing. Experts emphasize that expanding access to genetic screening in these cases could profoundly influence treatment options, screening protocols, and familial risk assessment. Dr. Kathleen Cooney from Duke University highlights that identifying inherited mutations enables earlier screening, personalized treatment plans, and family member alertness through genetic testing. The findings propose a potential shift in future screening guidelines, recognizing the broader spectrum of hereditary cancer risks. Ultimately, this research advances our understanding of genetic contributions to cancer and underscores the importance of genetic testing for patients with multiple cancer diagnoses.