Innovative Hydrogel Device Provides Sustained Artificial Saliva for Dry Mouth Relief

Research published in ACS Applied Polymer Materials introduces a revolutionary in-mouth hydrogel designed to alleviate dry mouth, a condition medically known as xerostomia. This condition, characterized by insufficient saliva production, can result from various factors including medications, radiation, chemotherapy, or certain medical conditions. Traditional treatments often involve temporary solutions or side effects, highlighting the need for more effective therapies.

The newly developed hydrogel acts as a saliva reservoir, capable of storing and releasing artificial saliva gradually within the mouth. Crafted from a biocompatible polymer, poly(hydroxyethyl methacrylate), the gel appears as a clear, small blob similar in size to a U.S. quarter. It can comfortably fit in the inner cheek or beneath the tongue.

In laboratory tests, the hydrogel absorbed artificial saliva up to 400% of its original volume in six hours, showcasing its high storage capacity. When subjected to body temperature conditions (~98.6°F or 37°C), it released the stored saliva over a four-hour period, with release rates remaining consistent across multiple uses. Notably, the gel's biocompatibility was confirmed as it did not affect cultured cell survival or growth.

This innovation holds promise for providing a reusable, affordable, and easy-to-use solution for individuals suffering from dry mouth. The researchers aim to enhance the gel's durability, increase saliva release capacity, and develop fully dissolvable versions for even greater convenience.

Artificial saliva mimics natural saliva, mainly water with mucins that lubricate the mouth and offer antimicrobial benefits. Currently, artificial saliva used in labs has demonstrated potential to treat xerostomia effectively. This new hydrogel technology seeks to transform such potential into a practical, long-lasting treatment option, improving quality of life for millions affected by dry mouth.

For more detailed information, see the original study: Suman Debnath et al, Poly(hydroxyethyl methacrylate) Saliva-Gel: A Polymer-Based Solution for Xerostomia Treatment, ACS Applied Polymer Materials (2025).