Research Finds Harmful Chemical Created by Vaping Cannabinoid Mixtures That Can Damage Human Tissue

Recent scientific investigations have revealed concerning health risks associated with vaping cannabinoid mixtures, including those containing cannabis and CBD. A study conducted by researchers at the University of California - Merced, led by Professor Ryan Baxter, has demonstrated that under certain vaping conditions, cannabinoids such as CBD can oxidize to form a highly toxic compound called cannabidiol hydroxyquinone (CBD-Q). This chemical has been shown to cause destruction of human tissue, raising serious safety concerns about vaping products.

The researchers monitored how storage and usage conditions influence CBD stability and found that heat and oxidative stress during vaping promote the formation of CBD-Q. While CBD is generally considered non-toxic when stored properly, the process of vaping—especially when high temperatures are involved—can dramatically increase the production of this harmful byproduct. Dr. Baxter explained that the intense oxidative stress focused on CBD during vaping results in rapid degradation into CBD-Q, with typical vaping devices reaching temperatures between 200 to 300 degrees Fahrenheit.

In addition to temperature effects, storage practices play a vital role. CBD stored in oil suspensions remains relatively protected from oxidation, but when added to beverages like sodas or alcoholic drinks, CBD degrades more readily upon sitting, leading to increased levels of CBD-Q, which is not regulated by the FDA. This raises additional concerns given the popularity of CBD-infused drinks.

The implications of these findings extend to the widespread use of vaping products, both legal and unregulated. Many products are sold in dispensaries or convenience stores, often flavored and easy to use, which may inadvertently expose users to toxic substances. The study emphasizes that although CBD alone appears safe, the conditions of vaping can cause its transformation into dangerous chemicals. Baxter and his colleagues aim to explore further how cannabinoids affect vascular tissues and to develop strategies—such as additives that prevent the formation of toxic byproducts—to improve vaping safety.

Published in Chemical Research in Toxicology,t the research underscores the need for regulatory oversight and consumer awareness about the potential dangers of vaping cannabinoid products. As the use and commercialization of cannabis-related products grow, understanding these chemical transformations becomes increasingly crucial for public health safety.

Source: https://medicalxpress.com/news/2025-08-vaping-cannabinoid-mixtures-chemical-destroys.html