Innovative Fluorescent Eye Patch for Noninvasive Monitoring of Eye Health

Researchers have developed a groundbreaking noninvasive wearable eye patch equipped with a fluorescence sensor that leverages advanced metal organic framework (MOF) hydrogel technology. This innovative device utilizes Eu-Dy MOF gel embedded in the eye patch to analyze tears and monitor lysozyme levels, a key biomarker linked to various eye conditions and infections. When applied beneath the eyes, the patch collects tear fluids, and upon exposure to ultraviolet light, the fluorescence changes are captured via a smartphone camera. The system’s underlying principle relies on the 'antenna effect,' where organic ligands in the MOF absorb light and transfer energy to lanthanide ions like Eu³⁺ and Dy³⁺, resulting in visible fluorescence. The presence of lysozyme causes complex formation with the MOF, leading to a measurable quenching of fluorescence, allowing highly sensitive detection down to 1.5 nanomolar concentrations in real time. This method offers a simple, rapid, and noninvasive alternative to traditional tear analysis techniques, which often involve complex and invasive procedures. The technology holds potential for widespread applications in personal health monitoring, early disease detection, and ongoing eye health assessment. The research, led by Prof. Jiang Changlong from the Hefei Institutes of Physical Science, was published in Analytical Chemistry. Ultimately, this device aims to facilitate early diagnosis and intervention for eye diseases through accessible, real-time monitoring with tangible clinical benefits.