Enhancing Laser Treatment for Skin Discoloration: Insights from an In-Silico Meta-Analysis
A groundbreaking in-silico meta-analysis introduces the EICF index to optimize laser irradiation for treating skin discoloration, showing improved efficacy and safety in clinical settings.
Recent advances in dermatology and cosmetic surgery have highlighted the potential of picosecond laser (PSL) treatments for addressing skin discoloration caused by conditions such as nevus of Ota. These laser therapies utilize ultra-short pulses to target pigmented lesions effectively, but optimizing the irradiation parameters remains crucial for maximizing efficacy and minimizing side effects.
A significant challenge in previous research has been the inconsistent application of laser irradiation levels, which often included results from both over- and under-irradiated treatments. This inconsistency made it difficult to draw accurate conclusions about the optimal treatment conditions. To address this, a research team led by Postdoctoral Fellow Yu Shimojo, along with Professors Toshiyuki Ozawa and Daisuke Tsuruta from Osaka Metropolitan University, developed an innovative in-silico indicator called the Excessive Setting Index of Clinical Fluence (EICF). This index, based on mathematical modeling, assesses whether the laser fluence used in treatments aligns with what is theoretically necessary for optimal outcomes.
The team published their findings in JAAD Reviews, demonstrating that the EICF could be used to evaluate existing clinical irradiation parameters. They then conducted a meta-analysis of studies that adhered to these optimal conditions, comparing the efficacy of PSL with nanosecond laser (NSL) treatments. The results showed that under proper irradiation settings, PSL demonstrated superior effectiveness while maintaining safety equivalent to NSL.
According to Dr. Shimojo, this research provides scientific insights into why certain laser treatments are successful and explains the occurrence of side effects. The EICF tool aims to guide clinicians in selecting safer and more effective laser parameters, ultimately improving patient outcomes.
This breakthrough underscores the importance of precise laser settings in skin discoloration treatments and may lead to standardized protocols that enhance treatment results across dermatological practices.
Source: https://medicalxpress.com/news/2025-07-optimizing-laser-irradiation-silico-meta.html
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