Early-Onset Pediatric Atopic Dermatitis Increases Risk for Uveitis

A recent study published in JAMA Ophthalmology has highlighted a significant link between early-onset atopic dermatitis (AD) in children and an increased risk of developing pediatric uveitis, an inflammatory eye condition that can threaten vision. The research was conducted by Dr. Yung-Yu Chu and colleagues at Chi Mei Medical Center in Tainan City, Taiwan, involving a large cohort of 114,889 children diagnosed with early-onset AD, with each case matched to a control group without AD.

The study found that children with early-onset AD had nearly twice the risk of developing uveitis compared to children without AD (0.08% vs. 0.05%), with a hazard ratio of 1.92. Notably, children with severe AD exhibited an even higher risk, with a hazard ratio of 3.64, indicating that the severity of skin condition correlates with eye inflammation risk. The increased risk remained significant even among children not treated with dupilumab or without autoimmune conditions, suggesting that the association is strongly linked to the early-onset AD itself.

These findings suggest the importance of regular eye examinations for children diagnosed with early-onset AD to facilitate early detection and management of uveitis. Dr. Chu emphasized that ophthalmologic monitoring might be especially beneficial for children with severe AD to prevent potential vision complications.

The study underscores the need for healthcare providers to be aware of this connection and consider interdisciplinary approaches in managing pediatric patients with atopic dermatitis. Further research is warranted to explore underlying mechanisms and preventive strategies.

Source: Medical Xpress

Journal: JAMA Ophthalmology, 2025

Read the full study here