Early Life Exposure to Dogs and Its Potential to Reduce Genetic Risk of Eczema
New research indicates that early exposure to dogs may protect children genetically predisposed to eczema by influencing immune-related genetic mechanisms, offering potential avenues for prevention.
Recent research published in the journal Allergy suggests that early environmental exposure, particularly to household pets like dogs, may influence a child's genetic susceptibility to developing atopic eczema—a condition characterized by dry, itchy, and inflamed skin. While genetics play a significant role in eczema risk, environmental factors can modify this risk, either amplifying or mitigating it.
The study analyzed data from 16 European research projects, examining the interactions between 24 genetic variants associated with eczema and 18 environmental factors experienced in early childhood. The findings indicated that certain environmental exposures, including dog ownership, antibiotic use, breastfeeding, having an elder sibling, smoking in the household, and washing routines, interact with genetic factors to influence eczema development. Notably, dog exposure appeared to have a protective effect.
Further analysis involving over 254,000 individuals revealed a significant interaction between dog exposure and a specific genetic variant on chromosome 5, near the gene encoding the interleukin-7 receptor—an important protein involved in immune regulation. Laboratory experiments demonstrated that this genetic variant affects the expression of the receptor in skin cells, and exposure to dogs may modify this effect, reducing skin inflammation associated with eczema.
These insights offer a promising avenue for understanding how modifying environmental factors like pet exposure could lower eczema risk in genetically predisposed children. Dr. Sara J. Brown, the study's lead author, explained, “This research provides a molecular understanding of how early life pet exposure might shield children from eczema, offering hope for preventive strategies in the future.” While more research is necessary to confirm and expand these findings, this study marks a significant step toward personalized prevention based on genetic and environmental interactions.
Source: https://medicalxpress.com/news/2025-06-early-exposure-dogs-lessen-genetic.html
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
Impact of RSV Vaccines and Nirsevimab on Reducing Hospitalizations in Infants
Maternal RSV vaccines and nirsevimab significantly reduce hospitalization rates among infants during the 2024–2025 season, highlighting the importance of early prevention strategies.
Sleep Disruption and Its Impact on Brain Blood Vessels and Dementia Risk
Fragmented sleep can damage brain blood vessels and increase the risk of dementia. A new study reveals cellular changes linked to sleep disturbance that accelerate cognitive decline in older adults.
Significant Variability in Commercial Prices for Surgical Procedures
A new study reveals significant variation in the pricing of surgical services across providers and facilities, highlighting concerns about market competition and healthcare costs.
