Early Life Exposure to Dogs and Its Potential to Reduce Genetic Risk of Eczema
New research indicates that early exposure to dogs may protect children genetically predisposed to eczema by influencing immune-related genetic mechanisms, offering potential avenues for prevention.
Recent research published in the journal Allergy suggests that early environmental exposure, particularly to household pets like dogs, may influence a child's genetic susceptibility to developing atopic eczema—a condition characterized by dry, itchy, and inflamed skin. While genetics play a significant role in eczema risk, environmental factors can modify this risk, either amplifying or mitigating it.
The study analyzed data from 16 European research projects, examining the interactions between 24 genetic variants associated with eczema and 18 environmental factors experienced in early childhood. The findings indicated that certain environmental exposures, including dog ownership, antibiotic use, breastfeeding, having an elder sibling, smoking in the household, and washing routines, interact with genetic factors to influence eczema development. Notably, dog exposure appeared to have a protective effect.
Further analysis involving over 254,000 individuals revealed a significant interaction between dog exposure and a specific genetic variant on chromosome 5, near the gene encoding the interleukin-7 receptor—an important protein involved in immune regulation. Laboratory experiments demonstrated that this genetic variant affects the expression of the receptor in skin cells, and exposure to dogs may modify this effect, reducing skin inflammation associated with eczema.
These insights offer a promising avenue for understanding how modifying environmental factors like pet exposure could lower eczema risk in genetically predisposed children. Dr. Sara J. Brown, the study's lead author, explained, “This research provides a molecular understanding of how early life pet exposure might shield children from eczema, offering hope for preventive strategies in the future.” While more research is necessary to confirm and expand these findings, this study marks a significant step toward personalized prevention based on genetic and environmental interactions.
Source: https://medicalxpress.com/news/2025-06-early-exposure-dogs-lessen-genetic.html
Stay Updated with Mia's Feed
Get the latest health & wellness insights delivered straight to your inbox.
Related Articles
Moderna Receives Limited Approval for Next-Generation COVID Vaccine in the US
Moderna’s new COVID-19 vaccine received limited FDA approval for high-risk groups, reflecting regulatory changes under HHS leadership amid ongoing vaccine debates. Learn about the vaccine's features and approval details.
Can Minnesota Address the Burnout Crisis Among Physicians in Time?
Minnesota faces a growing crisis of physician burnout, leading to early retirements and workforce shortages. Efforts are underway to support doctors' mental health and improve working conditions to retain medical professionals amid rising demand from an aging population.
New Genetic Markers and Vitamin B3 Offer Hope in Managing MASLD Progression
Researchers identify a genetic regulator, microRNA-93, that worsens MASLD, with vitamin B3 showing promise as an effective treatment to counteract disease progression.
How Molecular Randomness Influences Variations in Aging and Lifespan
New research reveals that randomness at the molecular and cellular levels significantly influences individual aging and lifespan, offering fresh insights into the biology of aging and potential personalized therapies.