Elevated DHEA-S Levels May Shorten Lifespan in Men, No Impact Observed in Women

Recent research indicates a significant link between higher levels of the hormone dehydroepiandrosterone sulfate (DHEA-S) and reduced lifespan in men. The study, led by Professor Mary Schooling from CUNY School of Public Health, employed a Mendelian randomization approach, analyzing genetic data from large European cohorts to determine causal relationships while minimizing confounding factors.

The findings revealed that genetically higher DHEA-S levels are associated with increased blood pressure and a shorter lifespan among men. Interestingly, the same connection was not observed in women, suggesting a gender-specific effect.

DHEA-S is a precursor to male and female sex hormones, such as testosterone, which implies that elevated levels could influence health outcomes differently across genders. The study's results align with FDA warnings about testosterone therapy potentially increasing blood pressure in men. These insights raise important questions about the regulatory status and over-the-counter availability of DHEA supplements in the United States.

While the evidence on DHEA-S and lifespan has been limited, this study provides robust genetic data supporting its impact on men's health. Further research is needed to explore potential interventions and guideline considerations regarding DHEA supplementation.

Source: Medical Xpress