New Research Suggests Concussions Could Signal Early Stages of ALS

Recent studies indicate that while traumatic brain injuries (TBI), such as concussions, have historically been linked to the development of amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease, the relationship might be more complex than previously thought. Traditionally considered a potential cause, new evidence suggests that the occurrence of concussions may actually serve as an early warning sign for individuals already in the initial phases of ALS. Researchers from the UK, led by Dr. William Stewart, analyzed data from approximately 85,700 patients with a history of TBI against over 257,000 matched controls without such injuries. Over a follow-up period of nearly six years, 150 cases of ALS were identified, with those who experienced TBI showing more than twice the risk of developing ALS compared to those without such injuries. Interestingly, this elevated risk was primarily observed within two years following the concussion. The findings imply that instead of TBI causing ALS, the early stages of ALS—potentially occurring subclinically—might increase the propensity for falls or accidents leading to TBI. Experts suggest that clinicians should monitor patients with TBI closely for signs of neurological decline, as early detection of degenerative brain diseases like ALS could improve management and outcomes. ALS is a progressive neurological disorder affecting muscle control, leading to weakness, difficulty walking, and eventually respiratory issues requiring ventilatory support. The study underscores the importance of understanding the bidirectional relationship between brain injuries and neurodegenerative diseases and highlights the potential need for early neurological assessment following TBI.

Source: https://medicalxpress.com/news/2025-10-concussions-early-als.html